Zonisamide for Weight Reduction in Obese Adults
نویسندگان
چکیده
منابع مشابه
Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial.
BACKGROUND Obese individuals who have failed to achieve adequate weight loss with lifestyle changes have limited nonsurgical therapeutic options. We evaluated the efficacy and tolerability of zonisamide, an antiepileptic drug, for enhancing weight loss in obese patients receiving diet and lifestyle guidance. METHODS This was a 1-year, randomized, double-blind, placebo-controlled trial conduct...
متن کاملZonisamide for weight loss in obese adults: a randomized controlled trial.
CONTEXT Zonisamide is a marketed antiepileptic drug that has serotonergic and dopaminergic activity in addition to blockade of sodium and calcium channels. Weight loss was an adverse effect associated with zonisamide treatment in epilepsy clinical trials. OBJECTIVE To evaluate the efficacy of zonisamide for weight loss in obese adults. DESIGN AND SETTING Sixteen-week randomized, double-blin...
متن کاملCombination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.
OBJECTIVE Zonisamide and bupropion have been investigated for weight reduction in obese adults. We conducted a preliminary study comparing the effect on body weight of the combination of these 2 drugs versus zonisamide monotherapy. METHOD This was a 12-week, randomized, open-label, parallel-group comparison of 2 active interventions conducted from October 2003 to June 2004. Eighteen obese wom...
متن کاملAuricular Acupressure for Weight Reduction in Obese Asian Young Adults: A Randomized Controlled Trial
Background: Treatment options for obesity include calorie reduction, increased activity, behavior modification, pharmacotherapy, and surgery. Alternative options such as ear acupuncture may be effective adjunct therapy. Objective: To test the efficacy of auricular acupressure for weight reduction in overweight and obese young adults. Design, Setting, and Participants: An 8-week randomized contr...
متن کاملGut Microbiota Composition in Obese and Normal Weight Adults in Iran
Background and purpose: Increasing prevalence of obesity over the past few decades constitutes a global health challenge. Recent evidence suggests that gut microbiota may contribute to weight control. So, the present study aimed at comparing the frequency of different bacteria in gut microbiota between obese and normal weight people in Iran. Materials and methods: Thirty normal weight (BMI of ...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 2012
ISSN: 0003-9926
DOI: 10.1001/2013.jamainternmed.99